NeOnc’s $629K Insider Buying Spree Follows Breakthrough Data and Now All Eyes Turn to the FDA

DENVER, Sept. 16, 2026 (GLOBE NEWSWIRE) -- (247marketnews.com) -- NeOnc Technologies Holdings (NASDAQ: NTHI) executives put even more personal capital behind the company, following positive Phase 2a results for its experimental brain-cancer therapy NEO100.

The latest purchase brings the total open-market buying by two senior executives to approximately $629,000 since the company announced its Phase 2a results on August 12.

CEO, President and Executive Chairman Amir F. Heshmatpour purchased another 35,000 shares on September 15 for approximately $115,400, at a weighted average price of roughly $3.30 per share. That pushes his post-results purchases to 111,000 shares for approximately $418,700, at an average cost of about $3.77 per share.

Founder, Chief Medical Officer and Chief Scientific Officer Thomas C. Chen, MD, PhD, purchased another 49,016 shares for approximately $210,000. Combined, the two executives have now purchased 160,016 shares for approximately $629,000, according to the company, and all of the purchases were made in the open market with personal funds.

Heshmatpour said the buying reflects his conviction following the clinical results, “The strength of our Phase 2a results reinforces my conviction in NeOnc's mission and the potential of our NEO platform,” he said. Heshmatpour added that his latest purchases bring his personal investment in NeOnc shares to more than $1.5 million over the past year.

The insider buying comes against the backdrop of a potentially important clinical milestone, as NeOnc reported that its NEO100-01 Phase 2a study met its primary endpoint, with six-month progression-free survival of 48.9%, compared with a pre-specified 20% benchmark for standard of care. The company reported a p-value of 0.0047 and median overall survival of 26.09 months.

NEO100 is being developed for central nervous system cancers, an area where treatment remains particularly challenging because of the blood-brain barrier. NeOnc's platform is designed around drug candidates and delivery approaches intended to address that barrier.

The company is not putting all of its clinical ambitions behind a single candidate. Its second program, NEO212, has completed Phase 1 dose escalation and established a recommended Phase 2 dose, giving NeOnc another potential development catalyst.

Meanwhile, the company recently announced a $15 million registered direct offering, providing additional capital as it advances its clinical programs.

That combination, positive Phase 2a data, substantial open-market insider purchases, fresh financing and another clinical program moving toward Phase 2, has put NTHI at an important inflection point and the message from management is unmistakable: executives are continuing to commit their own money to the company after the NEO100 readout.

Important Editorial Note: 247 highlights companies approaching significant catalysts and inflection points. This report reflects information available at the time of publication. Since developments can occur rapidly, readers should independently verify current information and review all company filings and disclosures.

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